Description

6-Fluoro-1-Hexanesulfonyl Chloride is a versatile organofluorine building block and key sulfonylating agent. This compound is essential for introducing the 6-fluorohexylsulfonyl moiety into target molecules, enabling the synthesis of advanced intermediates with tailored properties. It is primarily used by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in creating novel herbicides and fungicides by incorporating the fluoroalkylsulfonyl group for enhanced bioactivity and environmental stability.
• Material Science: Serves as a precursor for surface modifiers and polymer additives to impart hydrophobic or specific chemical functionalities.
• Chemical Biology & Proteomics: Acts as an activity-based probe (ABP) scaffold or labeling reagent for studying enzyme function and protein interactions.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring fluorinated sulfonyl chloride chemistry.

Basic Information

Product Name	6-Fluoro-1-Hexanesulfonyl Chloride
CAS No.	372-69-0
Molecular Formula	C₆H₁₂ClFO₂S
Molecular Weight	202.67 g/mol
Synonyms	6-Fluorohexane-1-sulfonyl chloride; 6-Fluorohexylsulfonyl chloride; 1-Fluoro-6-(chlorosulfonyl)hexane; 6-Fluoro-1-hexanesulfonic acid chloride; 6-Fluorohexanesulfonyl chloride; 372-69-0; 6-Fluoro-n-hexanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 6-Fluoro-1-Hexanesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data including HPLC purity, NMR, and IR spectroscopy for identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each shipment, and we support compliance with relevant regulatory frameworks for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and reacts with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.