Description

3-Methyl-L-Histidine is a naturally occurring, modified amino acid derivative of L-histidine, characterized by a methyl group on the imidazole ring. This specific structural modification makes it a valuable biochemical marker and a critical intermediate in advanced research and development. It is essential for industries focused on metabolic studies, biomarker analysis, and the synthesis of specialized peptides. The compound is primarily sought by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic research institutions for its role in investigating protein metabolism and related biological pathways.

Application

• Biochemical Research & Diagnostic Development: Used as a precise reference standard and key intermediate in studying histidine metabolism, protein turnover, and muscle catabolism.
• Pharmaceutical R&D: Serves as a crucial building block and analytical standard in the development of novel therapeutic agents and metabolic pathway modulators.
• Clinical Diagnostics: Employed in the calibration and validation of assays (e.g., LC-MS/MS) designed to measure 3-methylhistidine levels as a biomarker for muscle protein breakdown.
• Nutritional Science: Utilized in metabolic studies to assess protein requirements, muscle health, and the impact of dietary or therapeutic interventions.
• Peptide Synthesis: Acts as a specialized, modified amino acid for incorporating unique structural features into synthetic peptides for research purposes.
• Quality Control & Reference Standards: Provides a high-purity standard for analytical laboratories to ensure accuracy and compliance in testing protocols.

Basic Information

Product Name	3-Methyl-L-Histidine
CAS No.	368-16-1
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	L-3-Methylhistidine; 1-Methyl-L-histidine; (2S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid; 3-Methylhistidine; Nτ-Methyl-L-histidine; Hercynine; Thioneine; 3-MH
EINECS	206-701-6

Quality Control

Our 3-Methyl-L-Histidine is produced and tested under strict quality management systems. We provide material suitable for research and development applications, with a focus on high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.