Description

Boc-L-Phenylalanine n-Hydroxysuccinimide Ester (Boc-Phe-Osu) is a protected amino acid active ester widely used as a key building block in peptide synthesis. This compound is essential for introducing the phenylalanine residue with its N-terminal Boc (tert-butoxycarbonyl) protecting group intact, enabling controlled, stepwise chain elongation. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics, where high-purity, reliable intermediates are required for producing peptides, peptide mimetics, and labeled biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the automated synthesis of custom peptides and peptide libraries.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for the production of specific peptide sequences on a larger scale.
• Pharmaceutical Intermediates: Serves as a key building block in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Facilitates the site-specific attachment of peptides to proteins, antibodies, or other molecules for diagnostic and therapeutic applications.
• Proteomics Research: Employed in the synthesis of peptide standards, probes, and affinity tags for mass spectrometry and biochemical studies.
• Material Science: Used to create peptide-functionalized surfaces, polymers, and biomaterials.

Basic Information

Product Name	Boc-L-Phenylalanine n-Hydroxysuccinimide Ester
CAS No.	367-46-4
Molecular Formula	C₁₈H₂₂N₂O₆
Molecular Weight	362.38 g/mol
Synonyms	Boc-Phe-OSu; Boc-L-Phe-OSu; N-(tert-Butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester; N-Boc-L-phenylalanine succinimidyl ester; N-Boc-L-phenylalanine N-succinimidyl ester; N-α-Boc-L-phenylalanine N-hydroxysuccinimide ester; (2,5-Dioxopyrrolidin-1-yl) (2S)-3-phenyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
EINECS	Contact for details

Quality Control

Our Boc-L-Phenylalanine n-Hydroxysuccinimide Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, optical rotation, and impurity profiles. We adhere to industry-standard analytical methods including HPLC, NMR, and IR spectroscopy to verify identity and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in DMF)
Melting Point	142 - 148 °C
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.