Description

4-Chloro-3-Fluoroaniline is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents, makes it a valuable intermediate for creating compounds with tailored electronic and steric properties. This high-purity intermediate is essential for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drugs targeting central nervous system disorders, infections, and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity, stability, and selectivity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving performance and durability.
• Dye & Pigment Manufacturing: Employed in the production of specialized azo dyes and high-performance pigments that require halogenated aniline backbones for color fastness and stability.
• Polymer & Resin Modifiers: Incorporated into polymer chains to modify thermal stability, chemical resistance, and other material properties.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel fluorinated compounds.

Basic Information

Product Name	4-Chloro-3-Fluoroaniline
CAS No.	367-22-6
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	3-Fluoro-4-chloroaniline; 4-Chloro-3-fluoro-benzenamine; 1-Amino-4-chloro-3-fluorobenzene; Benzenamine, 4-chloro-3-fluoro-; 4-Chloro-3-fluorophenylamine; 367-22-6; 3-Fluoro-4-chlorophenylamine
EINECS	206-694-8

Quality Control

Our 4-Chloro-3-Fluoroaniline is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening containers to maintain purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.