Description

2,4,6-Trifluoroaniline CAS NO 363-81-5 is a key fluorinated aromatic amine building block, prized for its unique electronic and steric properties imparted by the trifluoro substitution pattern. This compound is essential for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms enhances metabolic stability, lipophilicity, and bioavailability. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new drugs, crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated drug candidates, particularly in oncology, central nervous system (CNS), and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used to manufacture advanced herbicides, fungicides, and insecticides where fluorine atoms improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing components in display and electronic materials, enhancing performance and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or surface properties.
• Dye & Pigment Intermediate: Employed in the production of high-performance, light-fast fluorinated dyes and pigments.
• Cross-coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed reactions to create complex aromatic amines.

Basic Information

Product Name	2,4,6-Trifluoroaniline
CAS No.	363-81-5
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	2,4,6-Trifluorobenzenamine; 1-Amino-2,4,6-trifluorobenzene; 2,4,6-Trifluoro-phenylamine; Benzenamine, 2,4,6-trifluoro-; α,α,α-Trifluoro-m-phenylenediamine (incorrect but sometimes listed); TFA; 2,4,6-F3C6H2NH2
EINECS	206-658-5

Quality Control

Our 2,4,6-Trifluoroaniline is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline mass
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.