Description

2,3,5-Trifluoroaniline is a versatile fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the specific fluorine substitution pattern, which is critical for modifying the biological activity and physical characteristics of target molecules. This high-purity intermediate is essential for research and production within the pharmaceutical, agrochemical, and specialty materials industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity, metabolic stability, and overall efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving charge transport, thermal stability, and optical properties.
• Polymer & Resin Modifier: Incorporated into high-performance polymers to impart chemical resistance, lower dielectric constants, and enhance thermal stability for electronics and aerospace applications.
• Dye & Pigment Industry: Employed in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and color properties.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	2,3,5-Trifluoroaniline
CAS No.	363-80-4
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	2,3,5-Trifluoroaniline; 2,3,5-Trifluorobenzenamine; 1-Amino-2,3,5-trifluorobenzene; 2,3,5-Trifluoro-phenylamine; Benzenamine, 2,3,5-trifluoro-; 2,3,5-Trifluoroaniline (TFA derivative); Aniline, 2,3,5-trifluoro-
EINECS	206-658-2

Quality Control

Our 2,3,5-Trifluoroaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep away from strong oxidizing agents, acids, and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.