Description

2',4',6'-Trifluoroacetanilide is a high-purity fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its trifluoromethyl-substituted aniline structure makes it a critical building block for creating complex molecules with enhanced stability and specific electronic properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atoms improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its influence on molecular polarity and alignment.
• Dye & Pigment Intermediate: Employed in the production of specialized fluorinated dyes and pigments that offer superior lightfastness and color properties.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex aromatic amines.
• Research & Development: A versatile reagent in academic and industrial R&D for exploring new fluorination chemistry and creating novel chemical entities.

Basic Information

Product Name	2',4',6'-Trifluoroacetanilide
CAS No.	363-40-6
Molecular Formula	C8H6F3NO
Molecular Weight	189.13 g/mol
Synonyms	N-(2,4,6-Trifluorophenyl)acetamide; 2,4,6-Trifluoroacetanilide; Acetamide, N-(2,4,6-trifluorophenyl)-; 1-Acetamido-2,4,6-trifluorobenzene; 2,4,6-Trifluoro-N-acetylaniline; 2,4,6-Trifluorophenylacetamide; NSC 406080; A13-00841
EINECS	Contact for details

Quality Control

Our 2',4',6'-Trifluoroacetanilide is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 146 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.