Description

3,5-Difluoro-2-Nitroaniline is a high-purity aromatic amine derivative, distinguished by its strategically positioned fluorine and nitro substituents. This compound matters as a versatile and critical building block in advanced organic synthesis, enabling the introduction of both fluorine atoms and aniline functionality into complex molecular architectures. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Dye and Pigment Manufacturing: Serves as a starting material for producing specialized azo dyes and pigments, where the difluoro-nitroaniline structure contributes to color fastness and unique spectral properties.
• Material Science Research: Employed in the creation of advanced polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic components for improved performance.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to construct complex nitrogen-containing heterocycles and functionalized anilines.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and as a standard in analytical chemistry for method development and calibration.

Basic Information

Product Name	3,5-Difluoro-2-Nitroaniline
CAS No.	361-72-8
Molecular Formula	C6H4F2N2O2
Molecular Weight	174.11 g/mol
Synonyms	2-Nitro-3,5-difluoroaniline; 3,5-Difluoro-2-nitrobenzenamine; 1-Amino-3,5-difluoro-2-nitrobenzene; 2-Amino-4,6-difluoronitrobenzene; Benzenamine, 3,5-difluoro-2-nitro-; 3,5-DFNA; 361-72-8 (CAS)
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Nitroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.