Description

Chlorodifluoroacetyl Chloride is a highly reactive and versatile acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in introducing the difluoroacetyl moiety, a key structural feature for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluoromethyl or difluoroacetyl groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in manufacturing advanced herbicides, fungicides, and insecticides where the difluoroacetate group contributes to efficacy and environmental profile.
• Fluorinated Building Block: Essential reagent for introducing fluorine atoms into complex organic molecules in medicinal and materials chemistry research.
• Polymer & Material Science: Employed in the production of specialty polymers, coatings, and advanced materials requiring specific fluorinated segments.
• Peptide & Protein Modification: Acts as an acylating agent for modifying amino acids or peptides to study structure-activity relationships.
• Liquid Crystal & Electronic Chemical: Intermediate in the synthesis of fluorinated compounds used in liquid crystal displays (LCDs) and electronic materials.

Basic Information

Product Name	Chlorodifluoroacetyl Chloride
CAS No.	354-24-5
Molecular Formula	C2Cl2F2O
Molecular Weight	148.93 g/mol
Synonyms	Difluoroacetyl Chloride, Chloride; Difluorochloroacetyl Chloride; 2-Chloro-2,2-difluoroacetyl Chloride; Chlorodifluoroacetic Acid Chloride; NSC 92440; α,α-Difluoro-α-chloroacetyl Chloride; Chlorodifluoroethanoyl Chloride
EINECS	206-555-2

Quality Control

Our Chlorodifluoroacetyl Chloride is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its reactivity as a strong acid/organic solvent, store separately from bases, amines, and alcohols. Use appropriate corrosion-resistant storage equipment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.55 g/cm³
Boiling Point	~40-42°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.