Description

4-Fluorobenzyl Chloride is a versatile and reactive organofluorine building block, essential for introducing the 4-fluorobenzyl moiety into complex molecules. Its high reactivity, particularly at the benzylic chloride site, makes it a critical intermediate for synthesizing advanced pharmaceutical compounds, agrochemicals, and specialty materials. This compound is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), including potential candidates for central nervous system (CNS) drugs, anti-cancer agents, and anti-inflammatory medications.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to modify electronic properties.
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymers, improving characteristics like chemical resistance, thermal stability, and surface properties.
• Cross-coupling Reagent: Acts as an electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create biaryl structures common in advanced materials.
• Protecting Group Chemistry: Utilized to temporarily protect alcohol or amine functionalities during multi-step synthetic sequences in complex molecule construction.

Basic Information

Product Name	4-Fluorobenzyl Chloride
CAS No.	352-11-4
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	α-Chloro-4-fluorotoluene; 1-(Chloromethyl)-4-fluorobenzene; p-Fluorobenzyl Chloride; (4-Fluorophenyl)methyl Chloride; 4-Fluorobenzylchloride; 4-Fluorophenylmethyl Chloride; FC6H4CH2Cl
EINECS	206-522-5

Quality Control

Every batch of 4-Fluorobenzyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis and degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.18 - 1.22 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.