Description

2-Methoxy-5-(Trifluoromethyl)Phenol is a versatile fluorinated phenolic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a methoxy group and a trifluoromethyl substituent on the phenol ring, makes it a valuable intermediate for creating molecules with enhanced properties. This compound is primarily sought after by research and development teams, as well as production chemists, in the pharmaceutical, agrochemical, and specialty materials industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic systems for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group contributes to efficacy and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Polymer Modification: Acts as a monomer or functionalizing agent to introduce phenolic and fluorinated characteristics into polymers, enhancing chemical resistance and surface properties.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electron-transport materials.
• Chemical Research: A valuable reagent for method development and exploring new reaction pathways in fluoroorganic chemistry.

Basic Information

Product Name	2-Methoxy-5-(Trifluoromethyl)Phenol
CAS No.	349-67-7
Molecular Formula	C8H7F3O2
Molecular Weight	192.14 g/mol
Synonyms	5-(Trifluoromethyl)-2-methoxyphenol; 2-Methoxy-α,α,α-trifluoro-p-cresol; 2-Methoxy-5-(trifluoromethyl)phenol; 3-Trifluoromethyl-4-hydroxylanisole; 4-Hydroxy-3-(trifluoromethyl)anisole; 5-Trifluoromethylguaiacol; Guaiacol, 5-trifluoromethyl-; Phenol, 2-methoxy-5-(trifluoromethyl)-
EINECS	206-493-4

Quality Control

Our 2-Methoxy-5-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under GMP or ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.