Description

3,5-Bis(Trifluoromethyl)Phenol is a versatile fluorinated phenolic compound characterized by its two electron-withdrawing trifluoromethyl groups, which impart unique chemical reactivity and stability. This high-value intermediate is critical for introducing lipophilicity and metabolic stability into advanced molecular architectures. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials sectors for synthesizing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics where the trifluoromethyl groups enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where its structural motif contributes to product efficacy and environmental persistence.
• Ligand & Catalyst Preparation: Serves as a precursor for creating sophisticated ligands in transition metal catalysis, enabling more efficient and selective chemical transformations.
• Functional Material Development: Incorporated into the backbone of specialty polymers, liquid crystals, and organic electronic materials to modify thermal stability, solubility, and optical properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring novel fluorinated compounds and reaction pathways.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenol
CAS No.	349-58-6
Molecular Formula	C8H4F6O
Molecular Weight	230.11 g/mol
Synonyms	3,5-Bis(trifluoromethyl)phenol; Phenol, 3,5-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-3,5-xylenol; 3,5-Di(trifluoromethyl)phenol; 3,5-Bis(trifluoromethyl)hydroxybenzene; Hexafluoro-3,5-dimethylphenol; NSC 404080
EINECS	206-493-9

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)Phenol is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our standard grades meet the stringent demands of fine chemical synthesis, and custom purity specifications can be discussed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	70 - 74 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.