Description

4-Chloro-2-Fluorophenol is a versatile halogenated phenol derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and stability.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystal compounds used in display technologies.
• Polymer Modifiers: Incorporated into polymer chains to impart specific characteristics such as flame retardancy or altered solubility.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a substrate for further functionalization in research laboratories.
• Dye and Pigment Intermediate: Used in the production of specialized dyes and pigments where halogen atoms influence color and fastness properties.

Basic Information

Product Name	4-Chloro-2-Fluorophenol
CAS No.	348-62-9
Molecular Formula	C6H4ClFO
Molecular Weight	146.55 g/mol
Synonyms	2-Fluoro-4-chlorophenol; 4-Chloro-2-fluorophenol; Phenol, 4-chloro-2-fluoro-; 2-Fluoro-4-chloro-1-hydroxybenzene; 4-Chloro-2-fluoro-1-hydroxybenzene; p-Chloro-o-fluorophenol; 1-Hydroxy-4-chloro-2-fluorobenzene
EINECS	206-485-1

Quality Control

Our 4-Chloro-2-Fluorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment, ensuring full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	32 - 36 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.