Description

4-Fluoroindoline-2,3-Dione is a versatile fluorinated heterocyclic compound, also known as 4-Fluoroisatin, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of a fluorine atom into the indoline-2,3-dione scaffold, enabling the development of novel compounds with modified biological activity and physicochemical properties. This high-purity intermediate is essential for research and production in the pharmaceutical and agrochemical industries, particularly for creating new active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including potential kinase inhibitors, antimicrobials, and central nervous system (CNS) agents.
• Agrochemical Research: Used to develop novel fluorinated pesticides and herbicides, where the fluorine atom can enhance metabolic stability and bioavailability.
• Organic Synthesis Building Block: Employed in the construction of complex heterocycles, such as quinolones and fused ring systems, for material science and medicinal chemistry applications.
• Chemical Biology Probes: Serves as a starting material for synthesizing fluorinated probes and tags used in biochemical assays and diagnostic research.
• Dye and Pigment Intermediate: Utilized in the research and development of specialized fluorinated dyes and functional organic materials.

Basic Information

Product Name	4-Fluoroindoline-2,3-Dione
CAS No.	346-34-9
Molecular Formula	C8H4FNO2
Molecular Weight	165.12 g/mol
Synonyms	4-Fluoroisatin; 4-Fluoro-1H-indole-2,3-dione; 4-Fluoro-2,3-dioxoindoline; Isatin, 4-fluoro-; 4-Fluoroindole-2,3-dione; 4-Fluoro-2,3-indolinedione
EINECS	Contact for details

Quality Control

Our 4-Fluoroindoline-2,3-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.