Description

α-Chloro-o-Fluorotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine atoms on the toluene ring, enabling selective functionalization for complex molecule construction. This compound is essential for research chemists and process development teams in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for active ingredient development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated and chlorinated aromatic motifs.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & Electronic Chemicals: Serves as a building block for fluorinated liquid crystal compounds and other specialty electronic materials.
• Organic Synthesis & Research: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic aromatic substitution reactions due to its reactive halogen sites.
• Dye & Pigment Intermediate: Utilized in the production of specialized halogenated dyes and pigments.
• Polymer Modification: Acts as a monomer or modifier in the synthesis of specialty polymers with unique properties.

Basic Information

Item	Details
Product Name	α-Chloro-o-Fluorotoluene
CAS No.	345-35-7
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	2-Chloro-α-fluorotoluene; (Chloromethyl)(2-fluorophenyl)methane; o-Fluorobenzyl Chloride; 2-Fluorobenzyl Chloride; 1-(Chloromethyl)-2-fluorobenzene; α-Chloro-2-fluorotoluene; 2-Fluoro-α-chlorotoluene; (2-Fluorophenyl)methyl chloride
EINECS	206-467-5

Quality Control

Our α-Chloro-o-Fluorotoluene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.