Description

5-(Trifluoromethyl)Isatin is a versatile and highly functionalized heterocyclic building block, distinguished by the presence of a reactive isatin core and a stable trifluoromethyl group. This combination is critical for modulating the physicochemical properties of target molecules, enhancing their metabolic stability, lipophilicity, and binding affinity. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other bioactive molecules targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a building block for organic semiconductors, dyes, and photoactive materials due to its electron-withdrawing characteristics and planar structure.
• Chemical Biology & Proteomics: Employed as a scaffold for designing activity-based probes and enzyme inhibitors to study biological pathways.
• Organic Synthesis: Utilized in palladium-catalyzed cross-coupling reactions, condensation reactions, and as a starting material for complex spirocyclic and fused heterocycles.

Basic Information

Product Name	5-(Trifluoromethyl)Isatin
CAS No.	345-32-4
Molecular Formula	C9H4F3NO2
Molecular Weight	215.13 g/mol
Synonyms	5-(Trifluoromethyl)-1H-indole-2,3-dione; 5-Trifluoromethylisatin; 1H-Indole-2,3-dione, 5-(trifluoromethyl)-; Isatin, 5-(trifluoromethyl)-; 5-Trifluorométhylisatine; 5-(Trifluormethyl)isatin; 345-32-4 (CAS)
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Isatin is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	245 - 250 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.