Description

4-(Acetylamino)-2-Fluorobenzenesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the sulfonamide pharmacophore, a key structural motif in many active pharmaceutical ingredients. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for the creation of novel sulfonamide-based molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides that utilize the sulfonamide functional group for bioactivity.
• Chemical Research: A versatile reagent for introducing sulfonyl groups in medicinal chemistry and process chemistry research programs.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of specialized sulfonated colorants.
• Material Science: Potential building block for creating functional polymers and advanced materials with specific surface properties.

Basic Information

Product Name	4-(Acetylamino)-2-Fluorobenzenesulfonyl Chloride
CAS No.	344-70-7
Molecular Formula	C8H7ClFNO3S
Molecular Weight	251.66 g/mol
Synonyms	N-[5-(Chlorosulfonyl)-2-fluorophenyl]acetamide; 2-Fluoro-4-acetamidobenzenesulfonyl chloride; 4-Acetamido-2-fluorobenzenesulfonyl chloride; p-Acetamido-o-fluorobenzenesulfonyl chloride; 2-Fluoro-4-(acetylamino)benzenesulfonyl chloride; 4-Acetylamino-2-fluorobenzenesulfonyl chloride; 344-70-7; NSC 406106
EINECS	206-456-8

Quality Control

Our 4-(Acetylamino)-2-Fluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.