Description

5-Fluorotryptophan is a halogenated derivative of the essential amino acid tryptophan, distinguished by the substitution of a fluorine atom at the 5-position of the indole ring. This structural modification makes it a valuable non-natural amino acid and a critical building block in pharmaceutical research and advanced biochemistry. It is primarily utilized by research institutions and industrial R&D departments focused on drug discovery, peptide engineering, and metabolic studies. The compound's unique properties facilitate the development of novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Peptide Synthesis & Modification: Used to incorporate fluorine into synthetic peptides to enhance their metabolic stability, bioavailability, and binding affinity.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, protein folding, and amino acid metabolism due to its fluorinated structure.
• Proteomics & Labeling: Acts as a building block for creating fluorophore-conjugated peptides or as a metabolic label in mass spectrometry-based proteomic studies.
• Antibody-Drug Conjugate (ADC) Development: Employed in the construction of linker-payload systems for targeted cancer therapies.
• Academic Research: Fundamental research in organic chemistry, medicinal chemistry, and chemical biology to explore structure-activity relationships.

Basic Information

Product Name	5-Fluorotryptophan
CAS No.	343-91-9
Molecular Formula	C₁₁H₁₁FN₂O₂
Molecular Weight	222.22 g/mol
Synonyms	5-Fluoro-DL-tryptophan; (RS)-5-Fluorotryptophan; DL-5-Fluorotryptophan; 5-Fluoro-1H-indole-3-alanine; 2-Amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid; 5-FTrp; 5-FT
EINECS	Contact for details

Quality Control

Our 5-Fluorotryptophan is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to ensure the material meets your specific research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.