Description

5-Fluorogramine is a specialized fluorinated indole alkaloid derivative, serving as a key synthetic intermediate in advanced organic chemistry. This compound is valued for its unique molecular structure, which incorporates a fluorine atom at the 5-position of the gramine scaffold, enabling precise modifications in target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel bioactive compounds and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Chemical Research & Development: Serves as a versatile scaffold in academic and industrial R&D for exploring new chemical spaces and reaction pathways.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Fluorinated Compound Library Synthesis: A key reagent for generating diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Material Science Precursor: Investigated as a precursor for advanced organic electronic materials and fluorinated polymers.

Basic Information

Product Name	5-Fluorogramine
CAS No.	343-90-8
Molecular Formula	C11H13FN2
Molecular Weight	192.23 g/mol
Synonyms	5-Fluoro-3-[(dimethylamino)methyl]indole; 5-Fluorogramine; 1H-Indole-3-methanamine, 5-fluoro-N,N-dimethyl-; 3-(Dimethylaminomethyl)-5-fluoroindole; 5-Fluoro-DL-gramine; Gramine, 5-fluoro-; 5-Fluorogramine (base); 5-Fluoro-gramine
EINECS	Contact for details

Quality Control

Our 5-Fluorogramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.