Description

Ethyl 4-Hydroxy-2-(Trifluoromethyl)Pyrimidine-5-Carboxylate is a high-value pyrimidine derivative and a key fluorinated building block in advanced organic synthesis. Its molecular structure, featuring a trifluoromethyl group and an ester moiety, makes it a versatile intermediate for creating compounds with enhanced biological activity and physicochemical properties. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients. Its reliable quality and consistent supply are critical for accelerating drug discovery and material science projects.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials that require fluorinated heterocycles.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	Ethyl 4-Hydroxy-2-(Trifluoromethyl)Pyrimidine-5-Carboxylate
CAS No.	343-67-9
Molecular Formula	C8H7F3N2O3
Molecular Weight	236.15 g/mol
Synonyms	5-Carbethoxy-4-hydroxy-2-(trifluoromethyl)pyrimidine; Ethyl 4-hydroxy-2-(trifluoromethyl)-5-pyrimidinecarboxylate; 4-Hydroxy-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester; 2-(Trifluoromethyl)-4-hydroxypyrimidine-5-carboxylic acid ethyl ester; 5-Pyrimidinecarboxylic acid, 4-hydroxy-2-(trifluoromethyl)-, ethyl ester; NSC 403697
EINECS	Contact for details

Quality Control

Every batch of Ethyl 4-Hydroxy-2-(Trifluoromethyl)Pyrimidine-5-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment ensures reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.