Description

Orphenadrine Hydrochloride is a pharmaceutical-grade active pharmaceutical ingredient (API) with the CAS registry number 341-69-5. It is a centrally acting skeletal muscle relaxant with anticholinergic properties, valued for its efficacy in managing musculoskeletal conditions. This compound is essential for manufacturers in the pharmaceutical industry developing formulations for pain relief and muscle spasm control.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in prescription muscle relaxant medications.
• Formulation of oral tablets and extended-release capsules for the management of acute musculoskeletal pain.
• Used in combination analgesic products for enhanced therapeutic effect.
• Key component in pharmaceutical R&D for studying neuromuscular blocking agents.
• Reference standard in analytical laboratories for quality control and method validation.
• Potential intermediate in the synthesis of more complex pharmaceutical compounds.

Basic Information

Product Name	Orphenadrine Hydrochloride
CAS No.	341-69-5
Molecular Formula	C18H23NO•HCl
Molecular Weight	305.84 g/mol (Free base: 269.38 g/mol)
Synonyms	N,N-Dimethyl-2-[(o-methyl-α-phenylbenzyl)oxy]ethylamine hydrochloride; Orfenadrina clorhidrato; Biorphen; Disipal; Norflex; Mephenamin; Orfenace; Norgesic; 2-[(2-Methylbenzhydryloxy)ethyl]dimethylamine hydrochloride
EINECS	206-437-5

Quality Control

Our Orphenadrine Hydrochloride is manufactured under strict quality systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting full compliance with release specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in its original packaging until use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Specific Rotation	-0.10° to +0.10° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.