Description

3-Fluoro-4-Methoxybenzyl Bromide is a versatile and high-value fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its reactive benzylic bromide group and the strategic fluorine and methoxy substituents, which enable precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting the central nervous system (CNS) and as kinase inhibitors.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic display and lighting materials.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.
• Peptide Mimetics & PROTACs: Utilized for introducing the 3-fluoro-4-methoxybenzyl group into peptide backbones or linker systems for targeted protein degradation.
• Chemical Biology Probes: Employed in the development of fluorescent tags and molecular probes for imaging and diagnostic applications.

Basic Information

Product Name	3-Fluoro-4-Methoxybenzyl Bromide
CAS No.	331-61-3
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	1-(Bromomethyl)-3-fluoro-4-methoxybenzene; (3-Fluoro-4-methoxyphenyl)methyl Bromide; 4-Methoxy-3-fluorobenzyl Bromide; α-Bromo-3-fluoro-4-methoxytoluene; 3-Fluoro-4-methoxybenzylbromide; 3-Fluoro-p-anisyl Bromide; 3-Fluoro-4-methoxybenzyl bromide; 331-61-3
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methoxybenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.