Description

3,5-Bis(Trifluoromethyl)Aniline is a high-value fluorinated aromatic amine building block, distinguished by the presence of two electron-withdrawing trifluoromethyl groups. This unique structure imparts exceptional chemical stability and lipophilicity, making it a critical intermediate for advanced synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule drugs where the trifluoromethyl groups improve potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where its structural motif contributes to product efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis, enabling novel synthetic transformations.
• Material Science: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials, leveraging its thermal and chemical stability.
• Dye and Pigment Intermediate: Functions in the production of high-performance, light-fast dyes and pigments for specialized industrial applications.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Aniline
CAS No.	328-74-5
Molecular Formula	C8H5F6N
Molecular Weight	229.12 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzenamine; α,α,α,α',α',α'-Hexafluoro-3,5-xylidine; 3,5-Bis(trifluoromethyl)phenylamine; Benzenamine, 3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)aniline; 3,5-Bis(trifluoromethyl)aniline (primary name); 3,5-Bistrifluoromethylaniline
EINECS	206-334-8

Quality Control

Our 3,5-Bis(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow crystalline solid or liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.