Description

6-Fluoroisatin is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its ability to introduce the isatin scaffold with a strategically placed fluorine atom, which can dramatically alter the biological activity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used to develop novel fluorinated pesticides and herbicides, where the fluorine atom can enhance bioavailability and environmental stability.
• Organic Synthesis Building Block: Serves as a versatile starting material for constructing complex heterocycles like quinolones and fused indole derivatives via ring expansion and condensation reactions.
• Material Science: Investigated as a monomer or precursor for specialty polymers and organic electronic materials due to its conjugated structure.
• Biochemical Probe Development: Utilized in creating fluorophore-labeled compounds and activity-based probes for studying enzymatic mechanisms.

Basic Information

Product Name	6-Fluoroisatin
CAS No.	324-03-8
Molecular Formula	C8H4FNO2
Molecular Weight	165.12 g/mol
Synonyms	6-Fluoro-1H-indole-2,3-dione; 6-Fluoroindole-2,3-dione; 6-Fluoroisatin; 6-Fluoro-2,3-dihydroindole-2,3-dione; 6-Fluoro-2,3-indolinedione; 1H-Indole-2,3-dione, 6-fluoro-; Isatin, 6-fluoro-
EINECS	206-300-9

Quality Control

Our 6-Fluoroisatin is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	255 - 260 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.