Description

(2R,3R)-2-Amino-3-Methylpentanoic Acid is a high-purity, non-proteinogenic amino acid characterized by its specific (2R,3R) stereochemistry. This compound is a critical chiral building block in the synthesis of complex pharmaceuticals and bioactive peptides, where stereochemical purity directly impacts biological activity and efficacy. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical industries, particularly for developing novel therapeutics and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially peptidomimetics and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a specific, branched-chain amino acid residue into peptide sequences.
• Biochemical Research: Serves as a standard or reagent in metabolic pathway studies, enzyme-substrate interaction research, and as a component of custom cell culture media.
• Asymmetric Catalysis: Employed as a chiral ligand or auxiliary in asymmetric synthesis to induce stereoselectivity in chemical reactions.
• Nutraceutical & Cosmetic Peptides: A potential building block for bioactive peptides used in specialized nutraceutical formulations and advanced cosmetic actives.

Basic Information

Product Name	(2R,3R)-2-Amino-3-Methylpentanoic Acid
CAS No.	319-78-8
Molecular Formula	C6H13NO2
Molecular Weight	131.17 g/mol
Synonyms	(2R,3R)-2-Amino-3-methylvaleric acid; D-allo-Isoleucine; (2R,3R)-allo-Isoleucine; (R,R)-2-Amino-3-methylpentanoic acid; (2R,3R)-3-Methylnorvaline; allo-D-Isoleucine; (2R,3R)-Amino-3-methylvaleric acid; UNII-04Y7590D77
EINECS	206-269-2

Quality Control

Our (2R,3R)-2-Amino-3-Methylpentanoic Acid is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including chiral HPLC and NMR, to ensure excellent chemical and stereochemical purity (>98.5%). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant industry guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (2R,3R) isomer
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.