Description

Thioproperazine CAS NO 316-81-4 is a phenothiazine derivative belonging to the class of antipsychotic agents. This compound is of significant interest in pharmaceutical research and development, particularly in the study of neuroleptic drugs and their mechanisms of action. It serves as a critical intermediate and reference standard for researchers and manufacturers in the life sciences, pharmaceutical, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced neuroleptic and antipsychotic drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in neuroscience research to study dopamine receptor antagonism and related neurological pathways.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Academic Research: Employed in university and institutional research projects investigating the structure-activity relationships of phenothiazine derivatives.
• Fine Chemical Synthesis: Utilized as a specialized intermediate for the custom synthesis of complex molecules in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	Thioproperazine
CAS No.	316-81-4
Molecular Formula	C22H30N4O2S2
Molecular Weight	446.63 g/mol
Synonyms	Thioproperazine; Thioproperazine Mesylate; 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(methylsulfanyl)-10H-phenothiazine; 2-Methylmercapto-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine; Tiapridal; Tiapridex; Majepil; Vontril
EINECS	206-267-6

Quality Control

Our Thioproperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.