Description

Berberine Sulfate Trihydrate is a high-purity, crystalline salt form of the bioactive isoquinoline alkaloid berberine. This compound is valued for its consistent quality and enhanced stability, making it a critical raw material for research and production. It is primarily utilized in the pharmaceutical, nutraceutical, and life science industries for the development of standardized herbal extracts and active pharmaceutical ingredients.

Application

• Pharmaceutical Intermediates: Serves as a key starting material or active ingredient in the synthesis of prescription drugs and over-the-counter medications targeting metabolic and gastrointestinal health.
• Dietary Supplements & Nutraceuticals: Used in the formulation of capsules, tablets, and powders aimed at supporting healthy blood sugar and lipid metabolism.
• Biomedical & Clinical Research: Employed as a reference standard or experimental compound in pharmacological studies, particularly in metabolic syndrome, microbiology, and oncology research.
• Veterinary Medicine: Incorporated into animal health products for its antimicrobial and anti-inflammatory properties.
• Cosmeceutical Ingredients: Found in topical formulations for its potential skin-brightening and anti-acne benefits.
• Plant Extract Standardization: Acts as a marker compound for the quality control and standardization of herbal extracts from plants like *Coptis chinensis* and *Berberis vulgaris*.

Basic Information

Product Name	Berberine Sulfate Trihydrate
CAS No.	316-41-6
Molecular Formula	C20H18NO4 · H2SO4 · 3H2O
Molecular Weight	564.55 g/mol
Synonyms	Berberine hydrogen sulfate trihydrate; Berberine bisulfate trihydrate; Berberine sulfate hydrate; Natural Yellow 18 sulfate; Umbellatine sulfate; 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium sulfate trihydrate
EINECS	206-273-3

Quality Control

Our Berberine Sulfate Trihydrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical and nutraceutical applications. Comprehensive testing includes identification, assay, and impurity profiling. Certificates of Analysis (COA) documenting compliance with relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange-yellow crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water (KF)	8.0% - 11.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Microbial Limits	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.