Description

Methohexital Sodium is a fast-acting, ultra-short duration barbiturate derivative supplied as a white to off-white crystalline powder. This compound is a critical pharmaceutical active ingredient, primarily valued for its rapid onset and short duration of action, making it a preferred agent in specific medical procedures. It is essential for manufacturers in the pharmaceutical and life sciences sectors, particularly those developing or producing injectable anesthetic and sedative formulations for use in surgical and diagnostic settings.

Application

• Intravenous Anesthetic Agent: Primary use as a rapid-onset, short-acting general anesthetic for induction and maintenance of anesthesia in surgical procedures.
• Sedation for Medical Procedures: Used for procedural sedation in outpatient settings, such as electroconvulsive therapy (ECT) and other brief diagnostic or therapeutic interventions.
• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of more complex barbiturate-based pharmaceutical compounds.
• Research & Development: Utilized in preclinical and clinical research studies within pharmacology and neuroscience to study anesthetic mechanisms, GABA receptor function, and sedative-hypnotic effects.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development, validation, and assay of pharmaceutical products.

Basic Information

Product Name	Methohexital Sodium
CAS No.	309-36-4
Molecular Formula	C14H17N2NaO3
Molecular Weight	284.29 g/mol
Synonyms	Methohexitone Sodium; Sodium 5-Allyl-1-methyl-5-(1-methylpent-2-ynyl)barbiturate; Brevital Sodium; Brietal Sodium; Enallynymal Sodium; 1-Methyl-5-(1-methyl-2-pentyn-1-yl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione Sodium Salt; Methohexital Sodium Salt
EINECS	206-193-0

Quality Control

Our Methohexital Sodium is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling, to ensure it meets stringent pharmaceutical-grade specifications. We provide full traceability and support our products with detailed Certificates of Analysis (COA), which are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 2.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
pH (1% Solution)	10.0 - 11.5
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.