Description

α-Ketoglutaric Acid Disodium Salt is a key biochemical intermediate, the disodium salt form of α-ketoglutaric acid. This compound is essential in numerous metabolic pathways, most notably as a critical substrate in the Krebs cycle and a primary nitrogen acceptor in transamination reactions. It is widely utilized in the life sciences for cell culture media formulation, diagnostic reagent manufacturing, and as a precursor in pharmaceutical synthesis.

Application

• Cell Culture & Fermentation Media: Serves as a vital carbon source and metabolic intermediate in mammalian and microbial cell culture systems.
• Diagnostic Reagents: Used as a key component in enzymatic assay kits for clinical diagnostics, particularly for monitoring liver and kidney function.
• Biochemical Research: Acts as a fundamental substrate in studies of cellular metabolism, amino acid synthesis, and the TCA cycle.
• Pharmaceutical Intermediates: Employed as a building block in the synthesis of various active pharmaceutical ingredients (APIs) and nutraceuticals.
• Nutritional Supplements: Incorporated into specialized dietary and sports nutrition formulations for its role in energy metabolism.
• Plant Tissue Culture: Used in media for the in vitro growth and propagation of plant cells and tissues.

Basic Information

Product Name	α-Ketoglutaric Acid Disodium Salt
CAS No.	305-72-6
Molecular Formula	C5H4Na2O5 • xH2O
Molecular Weight	Anhydrous: 190.06 g/mol
Synonyms	2-Oxoglutaric Acid Disodium Salt; α-Ketoglutaric Acid Disodium Salt; AKG Disodium Salt; Oxoglutaric Acid Disodium Salt; Sodium 2-Oxopentanedioate; 2-Oxopentanedioic Acid Disodium Salt
EINECS	206-164-1

Quality Control

Our α-Ketoglutaric Acid Disodium Salt is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing including identification, assay, and impurity profiling to ensure it meets high-purity standards suitable for research and industrial applications. A Certificate of Analysis (COA) detailing specific results for purity, heavy metals, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. This product is hygroscopic (moisture-sensitive) and should be kept under conditions of low humidity. For long-term storage, a temperature of 2-8°C is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
pH (5% solution)	6.5 - 8.5
Water (KF)	≤ 2.0%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.