Description

3,5-Diiodo-L-Tyrosine Dihydrate is a halogenated derivative of the essential amino acid L-tyrosine, widely utilized as a key biochemical building block and research compound. This iodinated tyrosine derivative is valued for its role in the synthesis of thyroid hormone analogs and as a precursor in advanced pharmaceutical research. It is primarily sought by manufacturers and research institutions in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, metabolic studies, and the development of diagnostic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of thyroid hormone analogs (e.g., liothyronine) and other bioactive molecules.
• Biochemical Research: Used as a substrate or standard in enzymatic studies, metabolic pathway analysis, and hormone research.
• Radiopharmaceuticals: Serves as a starting material for the development of iodine-labeled compounds for diagnostic imaging.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR.
• Peptide Synthesis: Incorporated into custom peptides for structure-activity relationship (SAR) studies due to its unique halogenated side chain.
• Academic & Industrial R&D: Fundamental material for investigating iodine metabolism, protein iodination, and novel therapeutic agents.

Basic Information

Product Name	3,5-Diiodo-L-Tyrosine Dihydrate
CAS No.	300-39-0
Molecular Formula	C9H9I2NO4 • 2H2O
Molecular Weight	505.00 g/mol (Dihydrate)
Synonyms	L-3,5-Diiodotyrosine Dihydrate; 3,5-Diiodo-L-tyrosine Dihydrate; (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid Dihydrate; DIT; Diiodotyrosine; 3,5-Diiodo-4-hydroxyphenylalanine; 300-39-0; L-Diiodotyrosine Dihydrate
EINECS	206-101-2

Quality Control

Our 3,5-Diiodo-L-Tyrosine Dihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, the container must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Specific Rotation	-2.5° to -4.0° (c=1 in 1N HCl)
Water Content (KF)	6.0% - 8.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.