Description

3,5-Dibromo-L-Tyrosine is a halogenated derivative of the essential amino acid L-tyrosine, widely utilized as a key synthetic intermediate and research chemical. This compound is valued for its role in modifying peptide structures and studying enzyme inhibition, particularly in thyroid hormone biosynthesis. It serves as a critical building block for researchers and manufacturers in the pharmaceutical, biochemical, and life science sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly those targeting metabolic and endocrine pathways.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, especially for tyrosine hydroxylase and iodotyrosine deiodinase, to investigate thyroid hormone metabolism.
• Peptide Modification: Incorporated into synthetic peptides to introduce bromine atoms, altering their stability, receptor binding affinity, and biological activity for structure-activity relationship (SAR) studies.
• Proteomics & Labeling: Can be used as a heavy atom label in mass spectrometry or as a tag for tracking and isolating proteins in complex biological samples.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and research laboratories.

Basic Information

Product Name	3,5-Dibromo-L-Tyrosine
CAS No.	300-38-9
Molecular Formula	C9H9Br2NO3
Molecular Weight	338.98 g/mol
Synonyms	L-Tyrosine, 3,5-dibromo-; (2S)-2-Amino-3-(3,5-dibromo-4-hydroxyphenyl)propanoic acid; 3,5-Dibromotyrosine; H-DBT-OH; DBYT; 3,5-Dibromo-4-hydroxyphenylalanine; NSC 406106; Dibromotyrosine
EINECS	206-100-7

Quality Control

Our 3,5-Dibromo-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-10.0° to -14.0° (c=1 in 1N HCl)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.