Description

Desthiobiotin-Iodoacetamide is a high-purity, bifunctional chemical reagent designed for advanced bioconjugation and protein research. This compound is critical for researchers requiring precise, covalent modification of cysteine residues in proteins and peptides, enabling the study of protein function, structure, and interactions. It is an essential tool for scientists and manufacturers in the fields of proteomics, biochemical assay development, and the production of diagnostic reagents and biotherapeutics.

Application

• Proteomics Research: Site-specific labeling of cysteine-containing proteins for mass spectrometry analysis and structural studies.
• Bioconjugation Platform: Key intermediate for creating stable thioether linkages between biomolecules and surfaces, dyes, or other functional groups.
• Affinity Tagging: Used to introduce a desthiobiotin tag onto proteins for reversible capture and purification using streptavidin-based systems.
• Diagnostic Reagent Synthesis: Manufacturing component for enzyme conjugates and labeled antibodies used in immunoassays (ELISA, lateral flow tests).
• Chemical Biology Probes: Building block for creating activity-based probes to study enzyme function and mechanism.
• Drug Discovery: Tool compound for target identification and validation through covalent modification strategies.

Basic Information

Product Name	Desthiobiotin-Iodoacetamide
CAS No.	2924824-04-2
Molecular Formula	C13H22IN3O3S
Molecular Weight	427.30 g/mol
Synonyms	N-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-5-((2-iodoacetyl)amino)pentanamide; Iodoacetamide-Desthiobiotin; Desthiobiotin IAA; 5-((2-Iodoacetamido)pentanamido)-2-oxohexahydro-1H-thieno[3,4-d]imidazole; Desthiobiotin iodoacetamide probe; Biotinylation reagent (desthiobiotin variant); Cysteine-reactive desthiobiotin tag
EINECS	Contact for details

Quality Control

Our Desthiobiotin-Iodoacetamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant GMP and ISO guidelines for raw materials used in diagnostic and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.