Description

Cyclohexanecarboxylic Acid, 1-Methoxy-4-[4-Methyl-6-[(5-Methyl-1H-Pyrazol-3-Yl)Amino]-2-Pyrimidinyl]-, Methyl Ester, cis- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• API Development: Integral to the process development and scale-up of new active pharmaceutical ingredients, requiring strict control over stereochemistry (cis- isomer).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical market.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or molecular probes for biochemical and diagnostic research due to its functionalized structure.

Basic Information

Item	Details
Product Name	Cyclohexanecarboxylic Acid, 1-Methoxy-4-[4-Methyl-6-[(5-Methyl-1H-Pyrazol-3-Yl)Amino]-2-Pyrimidinyl]-, Methyl Ester, cis-
CAS No.	2778223-51-9
Molecular Formula	C19H25N5O3
Molecular Weight	371.44 g/mol
Synonyms	cis-1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexanecarboxylic acid methyl ester; Methyl cis-1-Methoxy-4-(4-methyl-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexanecarboxylate; (cis)-Methyl 1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]cyclohexanecarboxylate; CAS 2778223-51-9; 2778223-51-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical methods including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (cis- isomer)	≥ 98.0% (by HPLC/NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.