Description

4,5-Difluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde is a high-value, multi-functional organic building block that combines a benzaldehyde core with a pinacol boronate ester and fluorine substituents. This compound matters for its critical role as a key synthetic intermediate in modern cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to introduce the difluorobenzaldehyde moiety into novel pesticides and herbicides, leveraging fluorine's ability to enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated aromatic cores in electronic and photonic materials, improving performance and durability.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and functionalized materials where the boronate ester group allows for precise post-polymerization modifications.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new synthetic pathways and creating compound libraries for screening.
• Fluorinated Aromatic Compound Production: Acts as a key starting material for manufacturing a wide range of other fluorinated fine chemicals and advanced intermediates.

Basic Information

Item	Details
Product Name	4,5-Difluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde
CAS No.	2776201-91-1
Molecular Formula	C₁₃H₁₅BF₂O₃
Molecular Weight	268.07 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4,5-difluorobenzaldehyde; 4,5-Difluoro-2-(pinacolatoboryl)benzaldehyde; 4,5-Difluorobenzaldehyde-2-boronic acid pinacol ester; (4,5-Difluoro-2-formylphenyl)boronic acid pinacol ester; Pinacol (4,5-difluoro-2-formylphenyl)boronate; CAS 2776201-91-1
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.