Description

Fmoc-Phe(2-Me, 5-I)-Oh is a specialized, ortho-substituted aromatic amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing unique steric and electronic properties into peptide chains, enabling the development of novel bioactive molecules with enhanced stability and targeted functionality. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, particularly in the development of peptide-based therapeutics, diagnostic probes, and chemical biology tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, used to incorporate modified phenylalanine residues into peptide sequences.
• Pharmaceutical Research: Synthesis of non-natural peptide analogs for drug discovery programs targeting GPCRs, enzymes, and protein-protein interactions.
• Peptidomimetic Design: Creation of constrained peptide structures where the 2-methyl, 5-iodo substitution pattern influences backbone conformation and side-chain presentation.
• Chemical Biology Probes: Building block for synthesizing peptide-based probes where the iodine atom serves as a handle for further modifications via cross-coupling reactions.
• Agrochemical Research: Development of bioactive peptide derivatives for crop protection and growth regulation.
• Material Science: Incorporation into specialty polymers and supramolecular assemblies to impart specific self-assembly or recognition properties.

Basic Information

Product Name	Fmoc-Phe(2-Me, 5-I)-Oh
CAS No.	2642726-42-7
Molecular Formula	C25H22INO4
Molecular Weight	527.35 g/mol
Synonyms	Fmoc-2-methyl-5-iodo-L-phenylalanine; N-(9-Fluorenylmethoxycarbonyl)-2-methyl-5-iodo-L-phenylalanine; Fmoc-2-Me-5-I-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(2-methyl-5-iodophenyl)propanoic acid; N-α-Fmoc-2-methyl-5-iodo-L-phenylalanine; Fmoc-L-Phe(2-Me,5-I)-OH; Fmoc-Phe(2-Me,5-I)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Phe(2-Me, 5-I)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.