Description

Fmoc-n-Me-Phe(4-I)-Oh is a specialized, protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of a modified phenylalanine residue, specifically N-methyl-4-iodophenylalanine, into peptide chains. It is an essential building block for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and academic laboratories developing novel peptide-based therapeutics, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated synthesis of complex peptides.
• Medicinal Chemistry & Drug Discovery: Incorporation of iodinated, N-methylated phenylalanine analogs to modulate peptide bioactivity, stability, and pharmacokinetic properties.
• Peptide Library Construction: Used in combinatorial chemistry to create diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation & Probe Development: The iodine atom provides a handle for further functionalization via cross-coupling reactions (e.g., Sonogashira, Suzuki) to attach fluorophores, biotin, or other tags.
• Structural Biology Studies: Synthesis of peptides containing heavy atoms for X-ray crystallography or as probes for structure-activity relationship (SAR) studies.
• API Intermediate: Serves as a critical intermediate in the research and development stages of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-n-Me-Phe(4-I)-Oh
CAS No.	2642726-17-6
Molecular Formula	C25H22INO4
Molecular Weight	527.35 g/mol
Synonyms	Fmoc-N-methyl-4-iodo-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-iodo-L-phenylalanine; Fmoc-N-Me-4-I-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-(4-iodophenyl)propanoic acid; Fmoc-N-methyl-(4-iodo)-L-phenylalanine; N-Fmoc-N-methyl-4-iodophenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-Phe(4-I)-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.