Description

Pyrimidine, 2-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]- is a high-purity, chiral heterocyclic compound featuring a fused pyrimidine-oxazoline scaffold. This advanced pharmaceutical intermediate is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel small-molecule drug candidates, especially in oncology and CNS research.
• Asymmetric Catalysis Ligand Precursor: Serves as a precursor for developing novel chiral ligands and catalysts used in enantioselective synthesis.
• Agrochemical Research: Used in the research and development of new, stereospecific pesticides and herbicides.
• Academic & R&D: Employed in university and institutional laboratories for methodological studies in heterocyclic and medicinal chemistry.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	Pyrimidine, 2-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-
CAS No.	2634687-71-9
Molecular Formula	C13H11N3O
Molecular Weight	225.25 g/mol
Synonyms	(4S)-4,5-Dihydro-4-phenyl-2-(pyrimidin-2-yl)-1,3-oxazole; 2-[(4S)-4,5-Dihydro-4-phenyl-2-oxazolyl]pyrimidine; (S)-4-Phenyl-2-(pyrimidin-2-yl)-4,5-dihydrooxazole; (S)-2-(4,5-Dihydro-4-phenyloxazol-2-yl)pyrimidine; Chiral Pyrimidine-Oxazoline Derivative; (S)-Phenyloxazolylpyrimidine; (S)-PHOX-Pyrimidine analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Pyrimidine, 2-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing purity, enantiomeric excess (ee), and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.