Description

1-Naphthalenol, 7-Fluoro-3-(Methoxymethoxy)-8-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]- is a sophisticated, high-purity synthetic intermediate featuring a unique naphthalene core functionalized with fluorine, a protected hydroxyl group, and a silyl-protected alkyne moiety. This compound matters for its role as a critical building block in advanced organic synthesis, enabling the construction of complex molecular architectures with precise regiochemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly where fluorination and controlled functional group manipulation are required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the fluorine atom for enhanced bioactivity and stability.
• Material Science: Serves as a monomer or functional unit in the creation of specialty polymers and organic electronic materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Sonogashira, Suzuki) due to its halogen and alkyne functionalities for constructing complex organic molecules.
• Fluorine Chemistry Studies: Used as a model compound in research exploring the effects of fluorination on molecular properties and reactivity.
• Ligand and Catalyst Development: The functionalized naphthalene structure can be utilized to develop novel ligands for asymmetric catalysis.

Basic Information

Product Name	1-Naphthalenol, 7-Fluoro-3-(Methoxymethoxy)-8-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-
CAS No.	2621932-35-0
Molecular Formula	C24H33FO3Si
Molecular Weight	416.61 g/mol
Synonyms	7-Fluoro-3-(methoxymethoxy)-8-[(triisopropylsilyl)ethynyl]-1-naphthol; 8-[(Triisopropylsilyl)ethynyl]-7-fluoro-3-(methoxymethoxy)-1-naphthalenol; TIPS-Ethynyl Fluoronaphthol MOM Ether; Fluorinated Silyl-Alkyne Naphthol Derivative; Advanced Fluorinated Building Block; CAS 2621932-35-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.