Description

2-Pyrimidinamine, 5-Chloro-n-[3-Cyclopropyl-5-[[(3R,5S)-3,5-Dimethyl-1-Piperazinyl]Methyl]Phenyl]-4-(6-Methyl-1H-Indol-3-Yl)- is a complex, high-purity heterocyclic compound designed for advanced pharmaceutical research and development. Its intricate molecular structure, featuring a pyrimidinamine core linked to cyclopropyl, piperazinyl, and indolyl groups, makes it a critical intermediate or reference standard in the synthesis of novel therapeutic agents. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, neurology, and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of potential drug candidates, especially kinase inhibitors or receptor modulators.
• Biochemical Research: Used as a reference standard or a tool compound in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Development: Employed in the research and process development stages for new chemical entities (NCEs).
• Preclinical Studies: Utilized in in-vitro and in-vivo testing to evaluate pharmacokinetics, pharmacodynamics, and initial efficacy.
• Process Chemistry & Scale-Up: Acts as a benchmark for developing and optimizing robust, scalable synthetic routes under GMP-like conditions.
• Analytical Method Development: Provides a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods for quality control.

Basic Information

Item	Details
Product Name	2-Pyrimidinamine, 5-Chloro-n-[3-Cyclopropyl-5-[[(3R,5S)-3,5-Dimethyl-1-Piperazinyl]Methyl]Phenyl]-4-(6-Methyl-1H-Indol-3-Yl)-
CAS No.	2569527-64-4
Molecular Formula	C29H33ClN6
Molecular Weight	501.07 g/mol
Synonyms	5-Chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-2-pyrimidinamine; (3R,5S)-5-Chloro-N-(3-cyclopropyl-5-((3,5-dimethylpiperazin-1-yl)methyl)phenyl)-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine; 2569527-64-4; UNII-9K2C4Z5W5T; 9K2C4Z5W5T; CHEMBL3186668; AOB67739; BDBM50140489
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support development under GMP-grade requirements and can tailor specifications to meet the rigorous standards of preclinical and clinical-stage pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.