Description

4-Pentynoic Acid, 2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-, (2S)- is a sophisticated, optically pure building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring high-fidelity, chiral intermediates in complex molecular assembly. It is primarily utilized in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other high-value specialty chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for peptide-based drugs and targeted biologics.
• Peptidomimetic Synthesis: Used to introduce constrained, alkyne-containing amino acid analogs into peptide chains to enhance stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Serves as a versatile handle for bioorthogonal conjugation via click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) for labeling and studying biological systems.
• Material Science Research: Employed in the creation of functionalized polymers and smart materials that require precise spatial orientation of functional groups.
• Process Chemistry Development: Acts as a critical intermediate in scaling up the production of complex molecules under Current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	4-Pentynoic Acid, 2-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-, (2S)-
CAS No.	2550906-64-2
Molecular Formula	C22H21NO5
Molecular Weight	379.41 g/mol
Synonyms	(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]pent-4-ynoic acid; Fmoc-N-Me-4-pentynoyl-glycine-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-pentynoylglycine; Fmoc-N-methyl-4-pentynoyl-Gly-OH; Nα-Fmoc-Nα-methyl-4-pentynoylglycine; N-Fmoc-N-methyl-4-pentynoylglycine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)pent-4-ynoic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for critical research and development. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical purity, and identity confirmation. Quality is verified via advanced analytical techniques including HPLC, NMR, and mass spectrometry to meet the exacting standards required for pharmaceutical and bioconjugation applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.