Description

3-((3R,4R)-3-(7H-[4,7'-Bipyrrolo[2,3-D]Pyrimidin]-4'-Yl(Methyl) Amino)-4-Methylpiperidin-1-Yl)-3-Oxopropanenitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure, designed for precision synthesis. This compound is critical for research and development in targeted drug discovery, particularly in kinase inhibitor programs. It serves as a key building block for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries, enabling the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule kinase inhibitors for oncology and other therapeutic areas.
• Drug Discovery Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop potent and selective drug candidates.
• Process Chemistry: Serves as a critical starting material or intermediate in the scale-up and commercial route development for Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Employed as a tool compound or probe in enzymatic assays to study specific biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	3-((3R,4R)-3-(7H-[4,7'-Bipyrrolo[2,3-D]Pyrimidin]-4'-Yl(Methyl) Amino)-4-Methylpiperidin-1-Yl)-3-Oxopropanenitrile
CAS No.	2504210-48-2
Molecular Formula	C21H23N7O
Molecular Weight	389.46 g/mol
Synonyms	3-[(3R,4R)-3-[[7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl](methyl)amino]-4-methyl-1-piperidinyl]-3-oxopropanenitrile; (3R,4R)-3-((7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl)(methyl)amino)-4-methylpiperidine-1-carbonyl)acetonitrile; 3-Oxopropanenitrile derivative of (3R,4R)-3-((7H-[4,7'-Bipyrrolo[2,3-d]pyrimidin]-4'-yl)(methyl)amino)-4-methylpiperidine; Advanced Kinase Inhibitor Intermediate 2504210-48-2
EINECS	Contact for details

Quality Control

Our 3-((3R,4R)-3-(7H-[4,7'-Bipyrrolo[2,3-D]Pyrimidin]-4'-Yl(Methyl) Amino)-4-Methylpiperidin-1-Yl)-3-Oxopropanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical research. Comprehensive Certificates of Analysis (COA) with full traceability are provided, supporting development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere. The product is hygroscopic and should be handled in a dry environment to prevent moisture uptake. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.