Description

3-Piperidinamine, 1-(2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-N,4-Dimethyl-, (3R,4R)- is a high-purity, stereochemically defined pharmaceutical intermediate of significant commercial interest. This compound is a key chiral building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs for oncology and other therapeutic areas. The product is supplied with full analytical characterization to ensure batch-to-batch consistency and support regulatory filings.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of protein kinase inhibitors.
• Oncology Drug Discovery: Used as a core structural component in the synthesis of preclinical and clinical drug candidates targeting specific cancer pathways.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of advanced intermediates.
• Reference Standard: Can be used as an analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	3-Piperidinamine, 1-(2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-N,4-Dimethyl-, (3R,4R)-
CAS No.	2504210-32-4
Molecular Formula	C13H18ClN5
Molecular Weight	279.77 g/mol
Synonyms	(3R,4R)-1-(2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N,4-dimethylpiperidin-3-amine; (3R,4R)-1-(2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N,4-dimethyl-3-piperidinamine; UNII-8J9K0L8T7W; 8J9K0L8T7W; 1-(2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N,4-dimethyl-(3R,4R)-3-piperidinamine; (3R,4R)-1-(2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N,4-dimethyl-3-aminopiperidine
EINECS	Contact for details

Quality Control

Our 3-Piperidinamine, 1-(2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-N,4-Dimethyl-, (3R,4R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support our clients with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under inert atmosphere or controlled humidity conditions when necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.