Description

5-(Dimethylphosphoryl)Pyrimidine-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique phosphoryl and nitrile functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to build complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other targeted therapeutics.
• Agrochemical Research: Used in the development of new herbicides and fungicides with novel modes of action.
• Chemical Biology Probes: Serves as a precursor for creating molecular probes to study enzyme function and signal transduction pathways.
• Material Science: Potential monomer or additive for advanced polymers and functional materials.
• Organic Synthesis: Versatile reagent for constructing complex pyrimidine-based heterocycles in academic and industrial research.

Basic Information

Product Name	5-(Dimethylphosphoryl)Pyrimidine-2-Carbonitrile
CAS No.	2503202-14-8
Molecular Formula	C7H8N3OP
Molecular Weight	181.13 g/mol
Synonyms	2-Cyano-5-(dimethylphosphoryl)pyrimidine; Dimethyl(2-cyanopyrimidin-5-yl)phosphine oxide; 5-(Dimethylphosphinyl)-2-pyrimidinecarbonitrile; Pyrimidine-2-carbonitrile, 5-(dimethylphosphinyl)-; 2503202-14-8; 5-(Dimethylphosphoryl)-2-cyanopyrimidine
EINECS	Contact for details

Quality Control

Every batch of 5-(Dimethylphosphoryl)Pyrimidine-2-Carbonitrile is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity specifications suitable for research and development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.