Description

L-Aspartic Acid, n-Ethyl-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated, high-purity protected amino acid derivative designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular construction, particularly in the development of novel peptides and bioactive molecules. It serves as a key building block for pharmaceutical R&D, enabling the synthesis of complex compounds with high stereochemical fidelity. Its protected functional groups offer superior selectivity and yield in multi-step synthetic pathways.

Application

• Pharmaceutical Intermediate: A crucial building block in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Bioconjugation Reagent: Used for the site-specific modification of proteins, antibodies, and other biomolecules in drug development and diagnostics.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms through the incorporation of non-natural amino acid analogs.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced, biologically active compounds for crop protection.
• Material Science: Used in the synthesis of specialized polymers and dendrimers with tailored properties for biomedical applications.
• Process Development: Employed in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs) under cGMP conditions.

Basic Information

Product Name	L-Aspartic Acid, n-Ethyl-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	2490159-66-3
Molecular Formula	C25H29NO6
Molecular Weight	439.50 g/mol
Synonyms	Fmoc-Asp(OtBu)-OH; Fmoc-L-aspartic acid 4-tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 1-tert-butyl ester; Nα-Fmoc-L-aspartic acid β-tert-butyl ester; N-Fmoc-L-aspartic acid 4-tert-butyl ester; Fmoc-Asp(OtBu)-OH; Fmoc-Asp(OtBu)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]butanedioic acid 4-tert-butyl ester
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid, n-Ethyl-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Optical Rotation	[α]D20: -20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.