Description

Fmoc-L-Lys[C20-Otbu-Glu(Otbu)-Aeea-Aeea]-Oh is a sophisticated, multi-functional building block designed for advanced peptide synthesis and bioconjugation. This compound matters for its role in constructing complex, site-specifically modified peptides and antibody-drug conjugates (ADCs), enabling precise control over drug delivery and therapeutic targeting. It is essential for researchers and manufacturers in pharmaceutical development, particularly those focused on oncology, targeted therapies, and novel biopharmaceuticals. The product is supplied with a CAS number of 2460751-66-8.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linker systems with integrated, potent cytotoxic agents.
• Solid-Phase Peptide Synthesis (SPPS): Used as an Fmoc-protected amino acid derivative for the controlled, sequential assembly of complex peptide sequences, especially those requiring branched or modified lysine residues.
• Site-Specific Bioconjugation: Enables the precise attachment of payloads (e.g., drugs, fluorophores, PEG chains) to proteins, antibodies, or other biomolecules via its reactive functional groups.
• Development of Targeted Therapeutics: Critical for creating novel drug candidates in oncology and other therapeutic areas where targeted delivery is paramount to efficacy and safety.
• Research & Development of Peptide Mimetics: Facilitates the exploration of peptide-like structures with enhanced stability, bioavailability, or receptor binding affinity.
• Production of Diagnostic Agents: Can be utilized to develop imaging probes and contrast agents for diagnostic applications.

Basic Information

Product Name	Fmoc-L-Lys[C20-Otbu-Glu(Otbu)-Aeea-Aeea]-Oh
CAS No.	2460751-66-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fmoc-Lys(C20-Glu(Otbu)-Aeea-Aeea)-OH; Nα-Fmoc-Nε-[(2S)-2-[(2-{2-[2-(2-{[(2S)-5-tert-butoxy-4-[(tert-butoxy)carbonyl]-5-oxopentan-2-yl]oxy}ethoxy)ethoxy]ethoxy}ethoxy)carbonyl]-4-[(2S)-2-[(2-{2-[2-(2-{[(2S)-5-tert-butoxy-4-[(tert-butoxy)carbonyl]-5-oxopentan-2-yl]oxy}ethoxy)ethoxy]ethoxy}ethoxy)carbonyl]butanamido]butyl]-L-lysine; Fmoc-Lys(PEG2-Glu(Otbu)-PEG2)-OH (common abbreviation); Fmoc-L-Lysine derivative with C20 linker and glutamic acid di-tert-butyl ester; ADC linker-payload building block; Fmoc-protected branched amino acid-PEG conjugate
EINECS	Contact for details

Quality Control

Our Fmoc-L-Lys[C20-Otbu-Glu(Otbu)-Aeea-Aeea]-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry (MS) and/or NMR, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.