Description

7H-Pyrrolo[2,3-D]Pyrimidine-7-Propanenitrile, 4-[[(3R,4R)-1-(2-Cyanoacetyl)-4-Methyl-3-Piperidinyl]Methylamino]-β-Oxo- is a sophisticated, high-purity pharmaceutical intermediate designed for advanced synthesis. This compound is critical for researchers and manufacturers developing novel small-molecule therapeutics, particularly in oncology and targeted disease areas. It is essential for organizations engaged in the synthesis of complex, stereochemically defined active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Preclinical & Clinical Research: Used in the discovery and development phases for new chemical entities (NCEs) with specific biological activity.
• Process Chemistry: Serves as a critical starting material or advanced intermediate in scalable API manufacturing processes under GMP conditions.
• Chemical Biology: Utilized in the development of chemical probes for studying specific enzymatic pathways and protein functions.
• Custom Synthesis: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.
• Reference Standard: Sourced for analytical method development, validation, and quality control testing of final drug substances.

Basic Information

Item	Details
Product Name	7H-Pyrrolo[2,3-D]Pyrimidine-7-Propanenitrile, 4-[[(3R,4R)-1-(2-Cyanoacetyl)-4-Methyl-3-Piperidinyl]Methylamino]-β-Oxo-
CAS No.	2459302-77-1
Molecular Formula	C19H24N6O2
Molecular Weight	368.44 g/mol
Synonyms	4-[[(3R,4R)-1-(2-Cyanoacetyl)-4-methyl-3-piperidinyl]methylamino]-β-oxo-7H-pyrrolo[2,3-d]pyrimidine-7-propanenitrile; (3R,4R)-1-(2-Cyanoacetyl)-4-methyl-N-[(7-cyano-β-oxo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methyl]-3-piperidinecarboxamide; CAS 2459302-77-1; Advanced Pyrrolopyrimidine Intermediate; Kinase Inhibitor Intermediate KII-2459302
EINECS	Contact for details

Quality Control

Our 7H-Pyrrolo[2,3-D]Pyrimidine-7-Propanenitrile intermediate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided, and we support compliance with ICH guidelines and customer-specific quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.