Description

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-methyl-N-[(3R,4S)-4-methyl-3-piperidinyl]- is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the research and development of novel small-molecule therapeutics, particularly in oncology and other targeted disease areas. It is primarily utilized by pharmaceutical R&D teams, process chemists, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational new drugs (INDs) and potential active pharmaceutical ingredients (APIs).
• Oncology Research: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapies.
• Preclinical & Clinical Development: Used in the production of compounds for pharmacological studies, toxicology assessments, and clinical trial material.
• Process Chemistry & Scale-Up: Essential for route scouting, optimization, and the manufacture of multi-kilogram batches under cGMP conditions.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis: Base material for the preparation of more complex, proprietary derivatives and analogs.

Basic Information

Product Name	7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-methyl-N-[(3R,4S)-4-methyl-3-piperidinyl]-
CAS No.	2459302-75-9
Molecular Formula	C13H19N5
Molecular Weight	245.33 g/mol
Synonyms	N-Methyl-N-[(3R,4S)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; (3R,4S)-3-[(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino]-4-methylpiperidine; CAS 2459302-75-9; 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-methyl-N-[(3R,4S)-4-methyl-3-piperidinyl]-; Stereoisomer of a pyrrolopyrimidine piperidine derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical development. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We implement rigorous analytical methods including HPLC, GC, NMR, and MS to ensure identity, strength, quality, and purity. Specifications can be aligned with cGMP guidelines for clinical-stage material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.