Description

Pyrido[4,3-D]Pyrimidin-4(3H)-One, 7-Chloro-8-Fluoro-2-(Methylthio)- is a high-value, heterocyclic organic compound belonging to the pyridopyrimidinone class, serving as a critical pharmaceutical intermediate and research chemical. Its unique molecular scaffold, featuring halogen and sulfur substituents, makes it a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and kinase inhibitor research. This compound is essential for R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors and other targeted cancer therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Research: Employed as a reference standard or probe molecule in enzymatic and cellular assays.
• Agrochemical Research: Serves as a starting material for developing novel pesticides and herbicides.
• Academic Research: Utilized in universities and research institutes for heterocyclic chemistry and drug discovery projects.
• Custom Synthesis: A foundational compound for contract research and manufacturing organizations (CROs/CMOs) producing custom molecules for clients.

Basic Information

Item	Detail
Product Name	Pyrido[4,3-D]Pyrimidin-4(3H)-One, 7-Chloro-8-Fluoro-2-(Methylthio)-
CAS No.	2454491-18-8
Molecular Formula	C8H5ClFN3OS
Molecular Weight	245.66 g/mol
Synonyms	7-Chloro-8-fluoro-2-(methylthio)-3H-pyrido[4,3-d]pyrimidin-4-one; 7-Chloro-8-fluoro-2-(methylsulfanyl)-3,4-dihydropyrido[4,3-d]pyrimidin-4-one; 7-Chloro-8-fluoro-2-(methylthio)pyrido[4,3-d]pyrimidin-4(3H)-one; 2454491-18-8; 7-Chloro-8-fluoro-2-methylsulfanyl-3H-pyrido[4,3-d]pyrimidin-4-one
EINECS	Contact for details

Quality Control

Our Pyrido[4,3-D]Pyrimidin-4(3H)-One, 7-Chloro-8-Fluoro-2-(Methylthio)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.