Description

Pyrido[4,3-D]Pyrimidine-2,4(1H,3H)-Dione, 7-Chloro-8-Fluoro- is a high-purity, heterocyclic organic compound that serves as a critical building block in modern pharmaceutical research and development. Its value lies in its unique pyrido[4,3-d]pyrimidine-dione core, which is a privileged scaffold for designing novel bioactive molecules, particularly kinase inhibitors. This advanced intermediate is essential for medicinal chemists and R&D teams in the pharmaceutical and biotechnology sectors who are developing next-generation targeted therapies.

Application

This specialized chemical intermediate is primarily utilized in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs. Key application areas include:

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry R&D: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Research: Employed in the development of chemical probes to study specific enzyme pathways and biological targets.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing custom compounds for client projects.
• Library Synthesis: Used to generate focused chemical libraries for high-throughput screening (HTS) in early-stage drug discovery.

Basic Information

Product Name	Pyrido[4,3-D]Pyrimidine-2,4(1H,3H)-Dione, 7-Chloro-8-Fluoro-
CAS No.	2454397-75-0
Molecular Formula	C7H3ClFN3O2
Molecular Weight	215.57 g/mol
Synonyms	7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione; 7-Chloro-8-fluoro-1,3-dihydropyrido[4,3-d]pyrimidine-2,4-dione; 7-Chloro-8-fluoro-3,4-dihydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione; 7-Chloro-8-fluoro-1H,3H-pyrido[4,3-d]pyrimidine-2,4-dione; CAS 2454397-75-0
EINECS	Contact for details

Quality Control

Our production of Pyrido[4,3-D]Pyrimidine-2,4(1H,3H)-Dione, 7-Chloro-8-Fluoro- adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for sensitive R&D applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.