Description

4(3H)-Quinazolinone, 2-[(1R)-1-[4-Amino-3-(3-Fluoro-4-Methoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Propyl]-3-Cyclopropyl-5-Fluoro- is a high-purity, complex heterocyclic compound designed for advanced pharmaceutical research and development. This molecule is a key synthetic intermediate, valued for its precise stereochemistry and functional groups that are critical for modulating biological activity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries. The compound's structure makes it a valuable building block for the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel small-molecule drug candidates, particularly in oncology and kinase inhibitor research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex quinazolinone and pyrazolopyrimidine core.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Biochemical Tool Compound: Acts as a reference standard or probe molecule in high-throughput screening and target validation assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.

Basic Information

Product Name	4(3H)-Quinazolinone, 2-[(1R)-1-[4-Amino-3-(3-Fluoro-4-Methoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Propyl]-3-Cyclopropyl-5-Fluoro-
CAS No.	2429889-62-1
Molecular Formula	C26H24F2N8O2
Molecular Weight	518.52 g/mol
Synonyms	2-[(1R)-1-[4-Amino-3-(3-Fluoro-4-Methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro-4(3H)-quinazolinone; (R)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one; CAS 2429889-62-1; Advanced Kinase Inhibitor Intermediate; Fluorinated Quinazolinone Derivative; Pyrazolopyrimidine-Quinazolinone Hybrid
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical R&D and GMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent moisture uptake and potential oxidation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.